康氏立克次氏體IgG免疫熒光試劑盒

Rickettsia conorii IgG IFA Kit

廣州健侖生物科技有限公司

主要用途：用于檢測人血清中的康氏立克次氏體IgG抗體

產品規(guī)格：12 孔/張,10 張/盒

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康氏立克次氏體IgG免疫熒光試劑盒

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【公司名稱】 廣州健侖生物科技有限公司
【】    楊永漢 
【】 
【騰訊 】 2042552662
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-3室
【企業(yè)文化】

在這項工作中，科學家提出了一個通用的模型發(fā)現，由2型轉谷氨酰胺酶的作用造成異常的IP3受體介導的鈣信號轉導，導致細胞功能紊亂，隨后出現大腦功能障礙。轉谷氨酰胺酶2的激活通常與炎癥和應激有關，以及IP3通道上的轉谷氨酰胺酶2作用，可能會為常見于不同的神經變性疾病的發(fā)生和發(fā)展步驟提供一個證據。
這項研究的*Katsuhiko Mikoshiba說：“我們認為，我們在這項研究中所確定的機制，可以為我們提供一個研究大腦和身體的其他部位的其他疾病的通用模型，其中2型轉谷氨酰胺酶被上調。我們希望這種認知zui終可能為許多神經退行性疾病開發(fā)新的藥物療法，這些疾病為患者和社會帶來沉重的負擔。”
大約50年前，電子顯微鏡揭示了細胞內形成的類似斑點的結構，它們到處移動然后消失。但科學家們并不知道它們存在的意義——據稱這些移動的類似云的蛋白質集合對細胞生命至關重要，因此它們或可能提供疾病治療的新方法。
在期刊《細胞生物學》上發(fā)表在一項研究里，兩名研究人員呼吁不同背景的科研者，從生物學到細胞生物學，將關注點集中在這些構造的用途上，他們啟用了一個統(tǒng)一的術語“集合體”來指代它們。
“我想要了解尤文肉瘤里的這些集合體在做什么，尤文肉瘤是我正在關注研究的疾病，我認為所有研究人體生物學的其他科研人員應該也會想要知道集合體在健康人群和疾病人群里所發(fā)揮的功能。” 喬治敦倫巴狄綜合癌癥中心腫瘤學和兒科學學院的教授杰弗里·托雷茨基(Jeffrey Toretsky)這樣說道。

In this work, scientists propose a generic model that found that aberrant IP3 receptor-mediated calcium signaling caused by type 2 transglutaminase leads to cellular dysfunction followed by brain dysfunction. Activation of transglutaminase 2, which is usually associated with inflammation and stress, and transglutaminase 2 action on the IP3 channel, may provide evidence of the common occurrence and progression of various neurodegenerative diseases.
Katsuhiko Mikoshiba, leader of the study, said: "We think the mechanism we identified in this study can provide us with a generic model for studying other diseases of the brain and other parts of the body, of which type 2 transglutaminase Amidase is up-regulated, and we hope this perception could ultimay lead to the development of new drug regimens for many neurodegenerative diseases that put a heavy burden on patients and society. "
About 50 years ago, electron microscopy revealed similar spots in the cell structure, they move around and disappear. But scientists do not know the meaning of their existence - these moving cloud-like protein collections are said to be vital to cell life and therefore they may or may provide new ways of treating the disease.
In a study published in the journal Cell Biology, two researchers called for researchers of diverse backgrounds, from biology to cell biology, to focus on the uses of these constructs, enabling a unified The term "aggregate" refers to them.
"I want to know what these assemblies in Ewing's sarcoma are doing, and Ewing's sarcoma is a disease I'm focusing on, and I think all other researchers working on human biology should also want to know how the aggregates are found in healthy people and diseases People, "said Jeffrey Toretsky, a professor at the Oncology and Paediatrics School at the Georgetown Comprehensive Cancer Center in Georgetown.