乙型流感病毒IgA ELISA免疫診斷試劑盒

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?乙型流感病毒IgA ELISA免疫診斷試劑盒

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【公司名稱】 廣州健侖生物科技有限公司
【市場部】    楊永漢

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【騰訊  】 2042552662
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-103室

通過轉(zhuǎn)換儲能的白色脂肪成為燃燒卡路里的棕色或米色脂肪，Metrnl增加能量消耗，提高肥胖、糖尿病小鼠的代謝健康。這種激素，有可能適合作為肥胖和糖尿病的治療新靶標，Metrnl是通過激活免疫分子白細胞介素-4和白細胞介素13，以及位于脂肪組織的免疫細胞即巨噬細胞發(fā)揮這些積極的效果。
發(fā)表在同一雜志上的另一項研究，進一步揭示了免疫反應和肥胖的相關(guān)問題，舊金山加州大學Ajay Chawlazui近的研究探究了在應對寒冷環(huán)境中，免疫系統(tǒng)激活棕色脂肪?，F(xiàn)在Chawla和他的團隊發(fā)現(xiàn)了小鼠體內(nèi)米色脂肪活化的基本“線路”。他們發(fā)現(xiàn)，interleukin-4/13信號激活白色脂肪組織中的巨噬細胞，導致轉(zhuǎn)換白色脂肪成為米色脂肪所需的神經(jīng)系統(tǒng)分子的生成。這些發(fā)現(xiàn)揭示了重要的新見解，即免疫系統(tǒng)和神經(jīng)系統(tǒng)如何協(xié)同工作來刺激米色脂肪的形成。
此外，研究人員發(fā)現(xiàn)，這種免疫通路信號受損的小鼠產(chǎn)生較少的米色脂肪，具有較低的能量消耗，并且在寒冷的環(huán)境中，與正常小鼠相比無法維持自己的體溫。與此相反，用白細胞介素-4處理小鼠能增加米色脂肪的形成，降低體重，改善肥胖小鼠代謝健康。

Metrnl increases energy expenditure and improves the metabolic health of obese, diabetic mice by converting stored energy white fat to brown or beige fat that burns calories. This hormone, potentially suitable as a novel target for the treatment of obesity and diabetes, Metrnl exerts these positive effects by activating the immune molecules interleukin-4 and interleukin-13, as well as the immune cells located in adipose tissue, macrophages.
Another study, published in the same journal, further uncovered questions about the immune response and obesity. A recent study by Ajay Chawla at the University of California, San Francisco, explored the activation of brown fat by the immune system in response to cold conditions. Now Chawla and his team found the basic "line" of beige fat activation in mice. They found that interleukin-4/13 signaling activates macrophages in white adipose tissue, resulting in the production of neuronal molecules needed to convert white fats to beige fats. These findings reveal important new insights on how the immune system and the nervous system work together to stimulate the formation of beige fats.
In addition, the researchers found that mice with impaired immune signaling generated less beige fat, had lower energy expenditure, and were unable to maintain their body temperature in cold conditions compared to normal mice. In contrast, treatment of mice with interleukin-4 increased the formation of beige fat, decreased body weight, and improved the metabolic health of obese mice.